Nevirapine is a medicine used to treat Human Immunodeficiency Virus (HIV), the virus that causes AIDS (Acquired Immune Deficiency Syndrome).
Nevirapine is a sort of anti-HIV medication called a "non-nucleoside reverse transcriptase inhibitor" (NNRTI). It functions by lowering the amount of Human Immunodeficiency Virus (HIV) in the blood. A patient should take Nevirapine with other anti-HIV medicines. When taken with other anti-HIV medicines. Nevirapine can reduce viral load and increase the number of CD4 cells ("T cells"). CD4 cells are a type of immune helper cell in the blood. Following warnings should keep in mind while or before the use of this medication: Skin Reactions: Hazardous and life-threatening skin reactions such as fatal cases, have been observed, occurring most frequently during the initial 6 weeks of the therapy. In some patients with developing symptoms of hypersensitivity reaction Or severe skin reactions such as severe rash or rash accompanied by fever, general malaise, fatigue, blisters, oral lesions, muscle or joint aches, conjunctivitis, facial edema, or hepatitis, eosinophilia, granulocytopenia, lymphadenopathy, and renal dysfunction. must permanently discontinue the consumption of Nevirapine tablets and seek medical evaluation right away. St. John’s wort: Concomitant use of hypericum perforatum or St. John's wort containing products and Nevirapine should not be recommended. Co-administration of non-nucleoside reverse transcriptase inhibitors (NNRTIs), including Nevirapine, with hypericum perforatum is expected to substantially decrease NNRTI concentrations and may result in sub-optimal levels of Nevirapine and lead to loss of virologic response and possible resistance to it or to the class of NNRTIs. Resistance: Avoid the use of Nevirapine as a single agent in order to treat HIV or added on as a sole agent to a failing regimen. As with all other NNRTIs, resistant virus emerges rapidly when nevirapine is administered as a monotherapy. Hepatic Events: In a few cases fulminant and cholestatic hepatitis, hepatic necrosis and hepatic failure, have been reported in patients treated with Nevirapine. Based on some controlled clinical trials, symptomatic hepatic events occurred in 4% of patients who consumed Nevirapine. In a few cases, patients presented with the non-specific, prodromal symptoms of malaise, anorexia, fatigue, nausea, jaundice, hepatomegaly or liver tenderness with or without initially abnormal serum transaminase levels. Rash was observed in approximately half of the patients with symptomatic hepatic adverse events. Fever as well as flu-like signs and symptoms accompanied a few of these hepatic events. Precautions: The most serious adverse reactions associated with Nevirapine are as follows:
Read:- Indications of Nevirapine
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