To treat localized prostate cancer, radical prostatectomy is most commonly approached forms of treatment. The process aims to eliminate the prostate gland and the nearby lymph nodes where cancer could have spread to. However, in some cases, radiation therapy is also opted for after surgery that can have a negative toll on urinary and sexual functions of the patient. It must be mentioned here that this is not the case for men who undergo only radical prostatectomy. This has been published in a recent study of the Urologic Oncology.
It must be stated here that the timing of radiotherapy and radical prostatectomy is a grey area as of now because their impact on sexual, urinary and bowel functions has not yet been determined or understood thoroughly. The recent data collected are useful for a proper discussion between the urologists and patients. CEASAR- Comparative Effectiveness Analysis of Surgery and Radiation This prospective and population-based study has been conducted via thorough observation with men who had been diagnosed with localized prostate cancer. It has been found out that if radiation therapy has been conducted right after radical prostatectomy, the decline in sexual functions is reportedly more severe than in men who have undergone radiation therapy after a considerable amount of time (24 months) of RP. Not only is this but without any compromise in the oncologic control, the data suggestive of the fact that if the patient is given an approximate recovery time of about 2 years, the erectile function can be preserved. This particular study included 1482 men who underwent RP surgery to cure localized prostate cancer. Only 11.5% received adjuvant radiation therapy within a time span of 5 years. Among them, 113 had received salvage radiation therapy. The reported sexual, urinary and bowel functional outcomes, reported by patients, were examined by the doctor at 6, 12, 36 and 60 months after enrollment. Conclusion It has been concluded that the median time from radical prostatectomy to radiation therapy was 7.3 months while from RP to salvage RT, it was recorded as 28.5 months. Patients who received adjuvant radiation therapy were reported to have lower hormonal domain scores in the initial 2 years after radical prostatectomy compared to men who had undergone surgery alone or surgery along with salvage radiation therapy. The study proved the claim that patients who received RT post radical prostatectomy experience significant urinary and sexual problems as they had worse scores in all the domain and the timing of radiation therapy also did not count in this case. Read:- EGFR and Targeted cancer therapy
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