Across the world, an estimated 185 million people have been infected with hepatitis C virus. And about 175 million are chronically infected. This highest prevalence of hepatitis C is found in MICs (Middle-Income Countries).
Hepatitis C is blood borne. It is basically transmitted through the unscreened organs, blood and blood products; via injection drug use with shared needles, syringes, filter and other paraphernalia. In medical or dental settings where infection control procedures are inadequate. By tattooing with shared equipment, ink and inkwells and sexually, especially between HIV-positive men who have sex with men. Hepatitis C becomes chronic in 75% of adults, and 80% of children. Others are capable in order to automatically clear their infection, usually within the months. Reinfection is possible in people who automatically cleared HCV, or were successfully treated. The goal and intention of hepatitis C treatment is to cure the virus. Pegylated interferon and ribavirin is a partially effective regimen. Ribavirin: Ribavirin, also known as Tribavirin, is an antiviral medication used for the treatment of:
Side Effects: Common side effects of Ribavirin 200 mg include:
The recommended dose of Ribavirin tablets should be taken as your healthcare professionals prescribed. For those patients who are previously untreated with ribavirin and interferon the recommended duration of the treatment should be 24 to 48 weeks. The dose should be individualized to the patient depending on baseline disease characteristics, response to therapy, and tolerability of the regimen. In some pivotal clinical trials, the patients were advised to take copegus (Ribavirin tablets) with food; therefore, patients are advised to take this medication with food. How Does the Ribavirin Works: Ribavirin 200 mg was approved for medical use in 1986. This guanosine (ribonucleic) analog basically used in order to stop viral RNA synthesis and viral mRNA capping, that's why the drug is a nucleoside inhibitor. This prodrug (Ribavirin), metabolized resembles purine RNA nucleotides. As the form of ribonucleic (guanosine analog), it basically interferes with the RNA metabolism required for viral replication. More than five direct and indirect mechanisms have been proposed for its mechanism of action. The safety and effectiveness of peginterferon alfa-2a in combination with copegus for the treatment of hepatitis C virus infection were assessed in two randomized controlled clinical trials. All the patients were adults and had compensated liver disease, liver biopsy diagnosis of chronic hepatitis, detectable hepatitis C virus and were previously not treated with the interferon. Approximately 20% of patients in both studies had compensated cirrhosis. Contraindications: Ribasure (Ribavirin capsules) is contraindicated in:
Read:- Efavirenz Emtricitabine and Tenofovir combination uses
0 Comments
Leave a Reply. |
Details
ArchivesAuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |