Ribociclib is a kinase inhibitor class drug that is used for the treatment of breast cancer. It is used in combination with an aromatase inhibitor for initial endocrine-based therapy. It is generally used in the patient of postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2 negative having advanced or metastatic breast cancer.
Ribociclib is a targeted therapy medication that is used in the treatment of advanced hormone receptor-positive breast cancer. This drug is a cyclin-dependent kinase inhibitor that blocks the protein called cyclin-dependent kinase 4 and cyclin-dependent kinase 6 in the cell. By blocking these two proteins the cancerous cell stops dividing to form new cells. This helps in preventing the cell from moving G1 to S cell cycle phase. This inhibition slows cancer growth. A combination of Ribociclib with another aromatase inhibitor is found to be more effective in comparison with the agents. Dosage and Administration: This drug is available in tablet form of strength 200mg. Tablet is taken orally with or without food in combination with letrozole. Do Not Crush, crack, or munch the tablet. Swallow the tablet as a whole. The therapy is taken for 21 days followed by 7 days off treatment. If any serious reaction occurs then the use of this medication is discontinued. The dosage of Kryxana depends upon health problems, stage of cancer, General Health, and the type of cancer. If any tablet of this medication is missed then take the drug as soon as you remember. Do not take double doses at a time. If this drug is taken in overdose form and trouble breathing occurs then the patient should immediately consult a doctor. Ribociclib Side Effects: The common adverse reaction of Ribociclib(Kryxana 200 mg) are as follows:
Drug interaction: There are several drug interactions which are listed below:
Ribociclib Price: This medication is inexpensive and cost-friendly. The Ribociclib 200 mg is obtainable at all registered pharmaceutical companies. The order can also be placed through any authorized website of a pharma firm. Related:- Clinical Trials Using Ribociclib: The clinical trials on this list are studying Ribociclib, and are supported by the NCI. Clinical trials look at the new ways in order to prevent, detect, or treat the disease. Ribociclib together with Everolimus and Dexamethasone in Order to Treat Children and Young Adults with Relapsed/Refractory ALL (Acute Lymphoblastic Leukemia): This phase-I trial studies the appropriate dose and adverse reactions of ribociclib when used together with everolimus and dexamethasone, and to know how effectively they acts in order to treat children and young adults with ALL (Acute Lymphoblastic Leukemia) that has relapsed or come back or does not respond to the treatment (refractory). Ribociclib plus everolimus may block the growth of cancerous cells by resisting certain enzymes required for the cell growth. Anti-inflammatory medicines, such as dexamethasone reduce the body’s immune response and are used together with the other medications in order to treat some sorts of cancer. Considering ribociclib along with everolimus and dexamethasone can work as a possible treatment option for the relapsed/refractory ALL (acute lymphoblastic leukemia). Ribociclib Plus Letrozole in Order to Treat Ovarian Cancer: This carried out study demonstrates the response of Ribociclib and Letrozole treatment in patients with low grade serous cancer of the ovary, fallopian tube or peritoneum. A Trial to Demonstrate Efficacy and Safety of Ribociclib Together With Endocrine Therapy as Adjuvant Treatment in Patients With HR+Ve/HER2-Ve Early Breast Cancer: A phase-III multi-center, randomized, open label trial in order to demonstrate efficacy as well as safety of the ribociclib together with the endocrine therapy as adjuvant treatment in patients with HR+Ve/HER2-Ve Early Breast Cancer. Ribociclib in Order to Treat Patients with The ER+ Breast Cancer: This randomized phase-II trial studies how effectively ribociclib acts in order to treat patients with ER+ breast cancer. Ribociclib can resist the growth of the tumor cells in order to block certain enzymes required for the cell growth. NOTE: The piece of information mentioned about "A Complete Guide on Ribociclib" in this article is just for the informational purposes and is not served as a substitute for medical treatment, consultation, diagnosis of an experienced/qualified healthcare practitioner.
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